The present work describes a simple, precise and accurate HPLC method for estimation of montelukast. The separation was achieved by using C18 column with acetonitrile: water 90:10 v/v as a mobile phase at a flow rate of 1.5 ml/min. Detection was carried out at 285 nm. The retention time of montelukast was found to be 6.7 min. The proposed method was ascertained by evaluating validation parameters like linearity (1-100 µg/ml) with R2=0.999. The proposed method is successfully applied for the determination of drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
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